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CXCR3

CXCR3 Overview

English NameC-X-C motif chemokine receptor 3Approved Drugs0
Drugs in Clinical Trials2Target SynonymCKR-L2，G protein-coupled receptor 9，IP-10 receptor，CXCR-3，CXC-R3，CXCR3，C-X-C Motif Chemokine Receptor 3，Interferon-Inducible Protein 10 Receptor，GPR9，C-X-C Chemokine Receptor Type 3，Chemokine Receptor 3，CD183 Antigen，CMKAR3，Chemokine (C-X-C Motif) Receptor 3，Mig Receptor，IP10-R，CD182，CD183，Mig-R，MigR，Receptors， CXCR3
Highest Development StagePhase 1 Clinical
English NameC-X-C motif chemokine receptor 3
Target SynonymCKR-L2，G protein-coupled receptor 9，IP-10 receptor，CXCR-3，CXC-R3，CXCR3，C-X-C Motif Chemokine Receptor 3，Interferon-Inducible Protein 10 Receptor，GPR9，C-X-C Chemokine Receptor Type 3，Chemokine Receptor 3，CD183 Antigen，CMKAR3，Chemokine (C-X-C Motif) Receptor 3，Mig Receptor，IP10-R，CD182，CD183，Mig-R，MigR，Receptors， CXCR3
Approved Drugs0
Drugs in Clinical Trials2
Highest Development StagePhase 1 Clinical

CXCR3 Product List

  • Product Category

    Protein (4)Cell (2)

  • Product Status

    Launched (6)

  • Species

    Human (5)Mouse (1)

  • Tag

    - (5)His Tag & Flag Tag (1)

  • Conjugate

    Unconjugated (3)- (2)Biotin-labeled (1)

Total: 6
  • 1

CXCR3 Background

Chemokines are proteins which induce chemotaxis, promote differentiation of immune cells, and cause tissue extravasation. Given these properties, their role in anti-tumor immune response in the cancer environment is of great interest. Although immunotherapy has shown clinical benefit for some cancer patients, other patients do not respond. One of the mechanisms of resistance to checkpoint inhibitors may be chemokine signaling. The CXCL9, -10, -11/CXCR3 axis regulates immune cell migration, differentiation, and activation, leading to tumor suppression (paracrine axis). However, there are some reports that show involvements of this axis in tumor growth and metastasis (autocrine axis). Thus, a better understanding of CXCL9, -10, -11/CXCR3 axis is necessary to develop effective cancer control.

CXCR3 Synonyms

CD182, CD183, CKR-L2, CMKAR3, GPR9, IP10-R, Mig-R, MigR
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