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CEACAM-6

CEACAM-6 Overview

English NameCarcinoembryonic antigen related cell adhesion molecule 6Approved Drugs0
Drugs in Clinical Trials4Target SynonymCEACAM6，CD66c，NCA，Carcinoembryonic Antigen Related Cell Adhesion Molecule 6，Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6 (Non-Specific Cross Reacting Antigen)，Normal Cross-Reacting Antigen，Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6，Non-Specific Crossreacting Antigen，Cluster Of Differentiation 66c，CD66c Antigen，CEAL，CEA Cell Adhesion Molecule 6
Highest Development StagePhase 2 Clinical
English NameCarcinoembryonic antigen related cell adhesion molecule 6
Target SynonymCEACAM6，CD66c，NCA，Carcinoembryonic Antigen Related Cell Adhesion Molecule 6，Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6 (Non-Specific Cross Reacting Antigen)，Normal Cross-Reacting Antigen，Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6，Non-Specific Crossreacting Antigen，Cluster Of Differentiation 66c，CD66c Antigen，CEAL，CEA Cell Adhesion Molecule 6
Approved Drugs0
Drugs in Clinical Trials4
Highest Development StagePhase 2 Clinical

CEACAM-6 Product List

  • Product Category

    Protein (5)

  • Product Status

    Launched (5)

  • Species

    Human (4)Rhesus macaque (1)

  • Tag

    His Tag (2)His Tag & Avi Tag (1)Fc Tag (1)Fc Tag & Avi Tag (1)

  • Conjugate

    Unconjugated (3)Biotin-labeled (2)

Total: 5
  • 1

CEACAM-6 Background

Carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) (CEACAM6) is also known as CD66c (Cluster of Differentiation 66c), CEAL, NCA, and is one of seven human CEACAM family members within the immunoglobulin superfamily. In humans, CEACAMs include type I transmembrane proteins (CEACAM1, CEACAM3, and CEACAM4) and GPI-linked molecules (CEACAM5 through CEACAM8). There is no human CEACAM2. CEACAM 6 contains one N-terminal V-type Ig-like domain (N domain), followed by two C2-type Ig-like domains. It shows considerable glycosylation, including (sialyl) LewisX, which mediates binding to E-selectin, galectins and some bacterial fimbrae. CEACAM-6 is expressed by granulocytes and their progenitors. It is also expressed by epithelia of various organs and is upregulated in pancreatic and colon adenocarcinomas, as well as hyperplastic polyps. Resistance to adhesion-related apoptosis in tumor cells is conferred in the condition of CEACAM6 overexpression.

CEACAM-6 Synonyms

CEACAM6,CD66c,CEAL,NCA
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  • Product List