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CD73

CD73 Overview

English Name5'-nucleotidaseApproved Drugs0
Drugs in Clinical Trials32Target Synonym5' Nucleotidase (CD73)，5'-nucleotidase，5'-Nucleotidase， Ecto (CD73)，Ecto-5'-nucleotidase，NT5E，5'-Nucleotidase Ecto，Ecto-5-Nucleotidase，5-NT，Purine 5-Prime-Nucleotidase，5-Nucleotidase， Ecto (CD73)，5 Nucleotidase (CD73)，5-Nucleotidase Ecto，5-Nucleotidase，CD73 Antigen，EC 3.1.3.5，CALJA，E5NT，ENT，NT，EN，CD73，5'-NT，NT5，NTE，EC:3.1.3.5
Highest Development StagePhase 3 Clinical
English Name5'-nucleotidase
Target Synonym5' Nucleotidase (CD73)，5'-nucleotidase，5'-Nucleotidase， Ecto (CD73)，Ecto-5'-nucleotidase，NT5E，5'-Nucleotidase Ecto，Ecto-5-Nucleotidase，5-NT，Purine 5-Prime-Nucleotidase，5-Nucleotidase， Ecto (CD73)，5 Nucleotidase (CD73)，5-Nucleotidase Ecto，5-Nucleotidase，CD73 Antigen，EC 3.1.3.5，CALJA，E5NT，ENT，NT，EN，CD73，5'-NT，NT5，NTE，EC:3.1.3.5
Approved Drugs0
Drugs in Clinical Trials32
Highest Development StagePhase 3 Clinical

CD73 Product List

  • Product Category

    Protein (8)Kits (1)Antibody (2)

  • Product Status

    Launched (11)

  • Species

    Human (4)Mouse (3)Cynomolgus (1)Canine (1)Rabbit (1)Rat (1)

  • Tag

    His Tag (6)His Tag & Avi Tag (1)Mouse IgG Fc Tag (1)- (3)

  • Conjugate

    Unconjugated (7)Biotin-labeled (1)- (1)PE Labeled (1)APC Labeled (1)

Total: 11
  • 1
  • 2

CD73 Background

5'-nucleotidase (5'-NT), also known as ecto-5'-nucleotidase or CD73 (cluster of differentiation 73), is an enzyme that is encoded by the NT5E gene. CD73 commonly serves to convert AMP to adenosine. Ecto-5-prime-nucleotidase (5-prime-ribonucleotide phosphohydrolase) catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate being AMP. Other forms of 5-prime nucleotidase exist in the cytoplasm and lysosomes and can be distinguished from ecto-NT5 by their substrate affinities, requirement for divalent magnesium ion, activation by ATP, and inhibition by inorganic phosphate. Rare allelic variants are associated with a syndrome of adult-onset calcification of joints and arteries (CALJA) affecting the iliac, femoral, and tibial arteries reducing circulation in the legs and the joints of the hands and feet causing pain.

CD73 Synonyms

CD73,NT5E,5'-Nucleotidase,5'-NT,NT5,NTE

Product Reviews

  • H***g2021-11-29
    0People Like
    Mouse CD73 / NT5E Protein, His Tag (active enzyme)
    It was used in research of investgational new drugs. Specifically, I have used this product in my Epitope binning experiments (using Octet) and I am truely satisfied with the results. With this experiment and your product, we have found a approximate epitope binding site. Thanks for your highly qualified product.
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