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CD46

CD46 Overview

English NameMembrane cofactor proteinApproved Drugs0
Drugs in Clinical Trials5Target SynonymTLX，MCP，CD46，CD46 Molecule，Membrane Cofactor Protein (CD46， Trophoblast-Lymphocyte Cross-Reactive Antigen)，Antigen Identified By Monoclonal Antibody TRA-2-10，CD46 Molecule， Complement Regulatory Protein，CD46 Antigen， Complement Regulatory Protein，Trophoblast Leukocyte Common Antigen，MIC10，Trophoblast-Lymphocyte Cross-Reactive Antigen，Complement Membrane Cofactor Protein，Trophoblast Leucocyte Common Antigen，Measles Virus Receptor，CD46 Antigen，TRA2.10，AHUS2，Membrane cofactor protein，MGC26544
Highest Development StagePhase 2 Clinical
English NameMembrane cofactor protein
Target SynonymTLX，MCP，CD46，CD46 Molecule，Membrane Cofactor Protein (CD46， Trophoblast-Lymphocyte Cross-Reactive Antigen)，Antigen Identified By Monoclonal Antibody TRA-2-10，CD46 Molecule， Complement Regulatory Protein，CD46 Antigen， Complement Regulatory Protein，Trophoblast Leukocyte Common Antigen，MIC10，Trophoblast-Lymphocyte Cross-Reactive Antigen，Complement Membrane Cofactor Protein，Trophoblast Leucocyte Common Antigen，Measles Virus Receptor，CD46 Antigen，TRA2.10，AHUS2，Membrane cofactor protein，MGC26544
Approved Drugs0
Drugs in Clinical Trials5
Highest Development StagePhase 2 Clinical

CD46 Product List

  • Product Category

    Protein (2)

  • Product Status

    Launched (2)

  • Species

    Human (2)

  • Tag

    His Tag (1)Fc Tag (1)

  • Conjugate

    Unconjugated (2)

Total: 2
  • 1

CD46 Background

Complement regulatory protein CD46 is also known as membrane Cofactor Protein (MCP), is a type I membrane protein and is a regulatory part of the complement system. CD46 is expressed by all cells except erythrocytes. MCP acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue, and also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. In T-cells by binding to CD46, A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype. Defects in CD46 are a cause of susceptibility to hemolytic uremic syndrome atypical type 2 (AHUS2).

CD46 Synonyms

CD46,AHUS2,MCP,MIC10,TLX,TRA2.10
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