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CD155

CD155 Overview

English NamePoliovirus receptorApproved Drugs0
Drugs in Clinical Trials2Target SynonymPVR Cell Adhesion Molecule，Poliovirus receptor，PVS，NECL-5，PVR，Nectin-Like Protein 5，CD155 Antigen，Nectin-Like 5，CD155，NECL5，TAGE4，HVED
Highest Development StagePhase 2 Clinical
English NamePoliovirus receptor
Target SynonymPVR Cell Adhesion Molecule，Poliovirus receptor，PVS，NECL-5，PVR，Nectin-Like Protein 5，CD155 Antigen，Nectin-Like 5，CD155，NECL5，TAGE4，HVED
Approved Drugs0
Drugs in Clinical Trials2
Highest Development StagePhase 2 Clinical

CD155 Product List

  • Product Category

    Protein (12)Cell (1)

  • Product Status

    Launched (13)

  • Species

    Human (6)Mouse (4)Rhesus macaque (3)

  • Tag

    His Tag (3)Fc Tag (2)Fc Tag & Avi Tag (2)Mouse IgG Fc Tag (2)His Tag & Avi Tag (3)- (1)

  • Conjugate

    Unconjugated (7)Biotin-labeled (5)- (1)

Total: 13
  • 1
  • 2

CD155 Background

CD155 is a Type I transmembrane glycoprotein in the immunoglobulin superfamily. Commonly known as Poliovirus Receptor (PVR) due to its involvement in the cellular poliovirus infection in primates, CD155's normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells. CD155/PVR was originally isolated based on its ability to mediate polio virus attachment to host cells. The fulllength (or CD155 alpha isoform) is synthesized as a 417 amino acid (aa) precursor that contains a 20 aa signal sequence, a 323 aa extracellular region, a 24 aa TM segment and a 50 aa cytoplasmic tail. The extracellular region contains one N terminal V type and two C2 type Ig like domains. CD155 is a transmembrane protein with 3 extracellular immunoglobulin-like domains, D1-D3, where D1 is recognized by the virus. Low resolution structures of CD155 complexed with poliovirus have been obtained using electron microscopy while a high resolution structures of theectodomain D1 and D2 of CD155 were solved by x-ray crystallography.

CD155 Synonyms

PVR,FLJ25946,PVS,CD155,TAGE4,HVED,NECL5

Product Reviews

  • 1***12019-09-26
    1People Like
    Human CD155 / PVR Protein, Fc Tag
    This protein was mainly used for molecule screening. Used in ELISA, this CD155 protein has strong binding ability with TIGIT, which can be easily applied to method development.
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