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Cathepsin B

Cathepsin B Overview

English NameCathepsin BApproved Drugs0
Drugs in Clinical Trials2Target SynonymEC 3.4.22，EC:3.4.22.1，RECEUP，Cathepsin B，Amyloid Precursor Protein Secretase，Epididymis Secretory Sperm Binding Protein，Cathepsin B1，Cysteine Protease，EC 3.4.22.1，CPSB，APPS，APP secretase，CTSB
Highest Development StagePhase 2 Clinical
English NameCathepsin B
Target SynonymEC 3.4.22，EC:3.4.22.1，RECEUP，Cathepsin B，Amyloid Precursor Protein Secretase，Epididymis Secretory Sperm Binding Protein，Cathepsin B1，Cysteine Protease，EC 3.4.22.1，CPSB，APPS，APP secretase，CTSB
Approved Drugs0
Drugs in Clinical Trials2
Highest Development StagePhase 2 Clinical

Cathepsin B Product List

  • Product Category

    Protein (2)

  • Product Status

    Launched (2)

  • Species

    Human (1)Mouse (1)

  • Tag

    His Tag (2)

  • Conjugate

    Unconjugated (2)

Total: 2
  • 1

Cathepsin B Background

Cathepsin B (CTSB) is also known as APP secretase (APPS) and CPSB, is an enzymatic protein belonging to the peptidase C1 family. Cathepsin B / CTSB is synthesized as a preproenzyme. Following removal of the signal peptide, the inactive proenzyme undergoes further modifications including removal of the pro region to result in the active enzyme. The catalytic activity of Cathepsin B / APPS contains: Hydrolysis of proteins with broad specificity for peptide bonds; Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L); In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides. As a thiol protease, cathepsin B / CPSB is believed to participate in intracellular degradation and turnover of proteins and has also been implicated in tumor invasion and metastasis. Overexpression of cathepsin B has been associated with esophageal adenocarcinoma and other tumors.

Cathepsin B Synonyms

CTSB,CPSB,APPS

Product Reviews

  • M***i2025-04-05
    0People Like
    Human Cathepsin B / CTSB Protein, His Tag (MALS verified)
    Product was purchased to utilize in a val-cit cleavage assay for a protein-drug conjugate. The protein did not take long to arrive and the assay instructions were clear to follow and promptly given upon request. I was readily able to utilize the protein for the desired cleavage assay using the provided protocol and it worked great. I am satisified with the quality and the price of this reagent.
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