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B7-H5

B7-H5 Overview

English NameV-domain Ig suppressor of T-cell activationApproved Drugs0
Drugs in Clinical Trials6Target SynonymDies1，VSIR，V-Set Domain-Containing Immunoregulatory Receptor，DD1alpha，B7-H5，PD-1H，B7H5，GI24，Stress-induced secreted protein-1，PP2135，SISP1，UNQ730/PRO1412，V-type immunoglobulin domain-containing suppressor of T-cell activation，V-Set Immunoregulatory Receptor，V-Domain Ig Suppressor Of T Cell Activation，PDCD1 Homolog，C10orf54，Sisp-1，VISTA，Chromosome 10 Open Reading Frame 54，Stress Induced Secreted Protein 1，Platelet Receptor Gi24，Death Domain1alpha
Highest Development StagePhase 2 Clinical
English NameV-domain Ig suppressor of T-cell activation
Target SynonymDies1，VSIR，V-Set Domain-Containing Immunoregulatory Receptor，DD1alpha，B7-H5，PD-1H，B7H5，GI24，Stress-induced secreted protein-1，PP2135，SISP1，UNQ730/PRO1412，V-type immunoglobulin domain-containing suppressor of T-cell activation，V-Set Immunoregulatory Receptor，V-Domain Ig Suppressor Of T Cell Activation，PDCD1 Homolog，C10orf54，Sisp-1，VISTA，Chromosome 10 Open Reading Frame 54，Stress Induced Secreted Protein 1，Platelet Receptor Gi24，Death Domain1alpha
Approved Drugs0
Drugs in Clinical Trials6
Highest Development StagePhase 2 Clinical

B7-H5 Product List

  • Product Category

    Protein (7)

  • Product Status

    Launched (7)

  • Species

    Human (5)Rhesus macaque (1)Mouse (1)

  • Tag

    His Tag (3)Fc Tag (1)His Tag & Avi Tag (1)Fc Tag & Avi Tag (1)Mouse IgG Fc Tag (1)

  • Conjugate

    Unconjugated (5)Biotin-labeled (2)

Total: 7
  • 1

B7-H5 Background

Platelet receptor Gi24, also known as B7-H5 and stress-induced secreted protein-1 (Sisp-1), is a protein that in humans is encoded by the C10orf54 gene, which contains 1 Ig-like (immunoglobulin-like) domain. As for C10orf54 gene, C10orf54 appears to positively interact with BMP-4, potentiating BMP signaling and the transition from an undifferentiated to a differentiated state on ESCs. Human C10orf54 undergoes proteolytic cleavage by MT1-MMP, generating a soluble 30 kDa extracellular fragment plus a 25-30 kDa membrane-bound fragment.

B7-H5 Synonyms

B7-H5,SISP1,Gi24,VISTA
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