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Alpha-Synuclein

Alpha-Synuclein Overview

English NameSynuclein alphaApproved Drugs0
Drugs in Clinical Trials23Target SynonymTruncated Alpha Synuclein，Α-Synuclein，Non-A Beta Component Of AD Amyloid，Synuclein Alpha-140，I+/--Synuclein，α-Synuclein，PARK4，PD1，alpha-Synuclein，Synuclein， Alpha (Non A4 Component Of Amyloid Precursor)，Non A-Beta Component Of AD Amyloid，PARK1，SNCA，Synuclein Alpha，NACP，Parkinson Disease (Autosomal Dominant， Lewy Body) 4，Non-A4 Component Of Amyloid Precursor，Non A4 Component Of Amyloid Precursor
Highest Development StagePhase 3 Clinical
English NameSynuclein alpha
Target SynonymTruncated Alpha Synuclein，Α-Synuclein，Non-A Beta Component Of AD Amyloid，Synuclein Alpha-140，I+/--Synuclein，α-Synuclein，PARK4，PD1，alpha-Synuclein，Synuclein， Alpha (Non A4 Component Of Amyloid Precursor)，Non A-Beta Component Of AD Amyloid，PARK1，SNCA，Synuclein Alpha，NACP，Parkinson Disease (Autosomal Dominant， Lewy Body) 4，Non-A4 Component Of Amyloid Precursor，Non A4 Component Of Amyloid Precursor
Approved Drugs0
Drugs in Clinical Trials23
Highest Development StagePhase 3 Clinical

Alpha-Synuclein Product List

  • Product Category

    Protein (17)Cell (1)

  • Product Status

    Launched (18)

  • Species

    Human (15)Cynomolgus (1)Mouse (2)

  • Tag

    His Tag (8)His Tag & Avi Tag (1)Fc Tag (1)Tag Free (7)GFP Tag (1)

  • Conjugate

    Unconjugated (13)Biotin-labeled (1)- (1)AF488 Labeled (1)AF647 Labeled (2)

Total: 18
  • 1
  • 2

Alpha-Synuclein Background

Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca2+ release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity.

Alpha-Synuclein Synonyms

SNCA,NACP,PARK1,alpha-Synuclein
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