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Human PROCR / EPCR / CD201 Protein, Fc Tag  pdf  pdf  pdf


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Synonym

PROCR, EPCR, CD201, APC receptor, CCCA, CCD41

Source

Recombinant Human PROCR /EPCR Protein, With C-Fc Tag (rhPROCR Fc Chimera) Ser 18 - Thr 209 (Accession # AAH14451) was produced in human 293 cells (HEK293) at ACRObiosystems.

Molecular Characterization

rhPROCR Fc Chimera, fused with Fc fragment of human IgG1 at the C-terminus, has a calculated MW of 48.6 kDa. The predicted N-terminus is Ser 18. As a result of glycosylation, DTT-reduced Protein migrates as 65 kDa and non-reduced protein migrates as 125 kDa.

Endotoxin

Less than 1.0 EU per μg of the rhPROCR Fc Chimera by the LAL method.

Purity

>95% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in 50 mM tris, 100 mM glycine, pH7.5. Normally Mannitol or Trehalose are added as protectants before lyophilization.

Contact us for customized product format or formulation.

Reconstitution

See Certificate of Analysis for details of reconstitution instruction and specific concentration.

Storage

Avoid repeated freeze-thaw cycles.

No activity loss was observed after storage at:
In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC).

 

SDS-PAGE


Recombinant Human PROCR /EPCR Protein, With C-Fc Tag
The purity of rhPROCR Fc Chimerawas determined by DTT-reduced (+) and non-reduced (-) SDS-PAGE and staining overnight with Coomassie Blue.
 
 

Background

Endothelial protein C receptor (PROCR) is also known as Activated protein C receptor (APC receptor), Endothelial cell protein C receptor, CD antigen CD201. PROCR / EPCR / CD201 is a N-glycosylated protein, with a soluble form exists. PROCR is probably released by a metalloprotease. PROCR seems to have the same activity as the membrane-bound form. PROCR / EPCR / CD201 is expressed strongly in the endothelial cells of arteries and veins in heart and lung. PROCR binds activated protein C and enhances protein C activation by the thrombin - thrombomodulin complex. PROCR plays a role in the protein C pathway controlling blood coagulation.

Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.


References

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