PROCR, EPCR, CD201, APC receptor, CCCA, CCD41
Recombinant Human PROCR /EPCR Protein, With C-Fc Tag (rhPROCR Fc Chimera) Ser 18 - Thr 209 (Accession # AAH14451) was produced in human 293 cells (HEK293) at ACRObiosystems.
rhPROCR Fc Chimera, fused with Fc fragment of human IgG1 at the C-terminus, has a calculated MW of 48.6 kDa. The predicted N-terminus is Ser 18. As a result of glycosylation, DTT-reduced Protein migrates as 65 kDa and non-reduced protein migrates as 125 kDa.
Less than 1.0 EU per μg of the rhPROCR Fc Chimera by the LAL method.
>95% as determined by SDS-PAGE.
Lyophilized from 0.22 μm filtered solution in 50 mM tris, 100 mM glycine, pH7.5. Normally Mannitol or Trehalose are added as protectants before lyophilization.
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See Certificate of Analysis for details of reconstitution instruction and specific concentration.
Avoid repeated freeze-thaw cycles.
No activity loss was observed after storage at:
In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC).
Endothelial protein C receptor (PROCR) is also known as Activated protein C receptor (APC receptor), Endothelial cell protein C receptor, CD antigen CD201. PROCR / EPCR / CD201 is a N-glycosylated protein, with a soluble form exists. PROCR is probably released by a metalloprotease. PROCR seems to have the same activity as the membrane-bound form. PROCR / EPCR / CD201 is expressed strongly in the endothelial cells of arteries and veins in heart and lung. PROCR binds activated protein C and enhances protein C activation by the thrombin - thrombomodulin complex. PROCR plays a role in the protein C pathway controlling blood coagulation.
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