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Human PROCR / EPCR / CD201 Protein  pdf  pdf  pdf


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Synonym

PROCR, EPCR, CD201, APC receptor, CCCA, CCD41

Source

Recombinant Human PROCR /EPCR /CD201 Protein (rhPROCR / EPCR) Ser 18 - Thr 209 (Accession # AAH14451) was produced in human 293 cells (HEK293) at ACRObiosystems.

Molecular Characterization

rhPROCR / EPCR, fused with 6×His tag at the C-terminus, has a calculated MW of 22.8 kDa. The predicted N-terminus is Ser 18 . DTT-reduced Protein migrates as 33-42 kDa kDa due to glycosylation.

Endotoxin

Less than 1.0 EU per μg of the rhPROCR / EPCR by the LAL method.

Purity

>95% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.

Contact us for customized product format or formulation.

Reconstitution

See Certificate of Analysis for details of reconstitution instruction and specific concentration.

Storage

Avoid repeated freeze-thaw cycles.

No activity loss was observed after storage at:
In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC).

 

SDS-PAGE


Recombinant Human PROCR /EPCR /CD201 Protein
The purity of rhPROCR / EPCR was determined by DTT-reduced (+) SDS-PAGE and staining overnight with Coomassie Blue.
 
 

Background

Endothelial protein C receptor (PROCR) is also known as Activated protein C receptor (APC receptor), Endothelial cell protein C receptor, CD antigen CD201. PROCR / EPCR / CD201 is a N-glycosylated protein, with a soluble form exists. PROCR is probably released by a metalloprotease. PROCR seems to have the same activity as the membrane-bound form. PROCR / EPCR / CD201 is expressed strongly in the endothelial cells of arteries and veins in heart and lung. PROCR binds activated protein C and enhances protein C activation by the thrombin - thrombomodulin complex. PROCR plays a role in the protein C pathway controlling blood coagulation.

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References

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