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Human PROCR / EPCR / CD201 Protein  pdf  pdf  pdf

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PRR-H5223-1mg (250ug x 4)
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PROCR, EPCR, CD201, APC receptor, CCCA, CCD41


Recombinant Human PROCR /EPCR /CD201 Protein (rhPROCR / EPCR) Ser 18 - Thr 209 (Accession # AAH14451) was produced in human 293 cells (HEK293) at ACRObiosystems.

Molecular Characterization

rhPROCR / EPCR, fused with 6×His tag at the C-terminus, has a calculated MW of 22.8 kDa. The predicted N-terminus is Ser 18 . DTT-reduced Protein migrates as 33-42 kDa kDa due to glycosylation.


Less than 1.0 EU per μg of the rhPROCR / EPCR by the LAL method.


>95% as determined by SDS-PAGE.


Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.

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See Certificate of Analysis for details of reconstitution instruction and specific concentration.


Avoid repeated freeze-thaw cycles.

No activity loss was observed after storage at:
In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC).



Recombinant Human PROCR /EPCR /CD201 Protein
The purity of rhPROCR / EPCR was determined by DTT-reduced (+) SDS-PAGE and staining overnight with Coomassie Blue.


Endothelial protein C receptor (PROCR) is also known as Activated protein C receptor (APC receptor), Endothelial cell protein C receptor, CD antigen CD201. PROCR / EPCR / CD201 is a N-glycosylated protein, with a soluble form exists. PROCR is probably released by a metalloprotease. PROCR seems to have the same activity as the membrane-bound form. PROCR / EPCR / CD201 is expressed strongly in the endothelial cells of arteries and veins in heart and lung. PROCR binds activated protein C and enhances protein C activation by the thrombin - thrombomodulin complex. PROCR plays a role in the protein C pathway controlling blood coagulation.

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