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Human CD200 / OX-2 Protein  pdf  pdf  pdf


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Synonym

CD200,MOX1,MOX2,MRC,OX-2,My033

Source

Human CD200 / OX-2 Protein (Human CD200, His Tag) Gln 31 - Gly 232 (Accession # AAH22522) was produced in human 293 cells (HEK293) at ACROBiosystems.

Molecular Characterization

Human CD200, His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 23.4 kDa. The predicted N-terminus is Gln 31. The reducing (R) protein migrates as 35-45 kDa in SDS-PAGE due to glycosylation.

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Purity

>98% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.

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Reconstitution

See Certificate of Analysis for reconstitution instructions and specific concentrations.

Storage

Avoid repeated freeze-thaw cycles.

No activity loss was observed after storage at:
In lyophilized state for 1 year (4°C); After reconstitution under sterile conditions for 3 months (-70°C).

 

SDS-PAGE


Human CD200 / OX-2 Protein
Human CD200, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 98%.
 
 

Background

CD200 is also known as OX-2 membrane glycoprotein (OX-2), is a type-1 membrane glycoprotein, which contains two immunoglobulin domains (1 Ig-like C2-type (immunoglobulin-like) domain and Ig-like V-type (immunoglobulin-like) domain), and thus belongs to the immunoglobulin superfamily. CD200 / OX-2 is widely expressed in multiple cell types. CD200 interacts with a structurally related receptor (CD200R) expressed mainly on myeloid cells and is involved in regulation of macrophage and mast cell function. OX-2 / CD200 and CD200R associate via their respective N-terminal Ig-like domains. CD200 also plays an important role in prevention of graft rejection, autoimmune diseases and spontaneous abortion.

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References

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