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Rhesus macaque EpCAM / TROP1 Protein  pdf  pdf  pdf


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Synonym

EPCAM,TACSTD1,TROP1,CD326,DIAR5,EGP2,EGP314,EGP40

Source

Rhesus macaque EpCAM / TROP1 Protein (Rhesus macaque EpCAM, His Tag) Gln 24 - Lys 265 (Accession # Q1WER1) was produced in human 293 cells (HEK293) at ACROBiosystems.

Molecular Characterization

Rhesus macaque EpCAM, His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 28.2 kDa. The predicted N-terminus is Gln 24. DTT-reduced Protein migrates as 28-40 kDa in SDS-PAGE due to different glycosylation.

Endotoxin

Less than 1.0 EU per μg of the Rhesus macaque EpCAM, His Tag by the LAL method.

Purity

>95% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.

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Reconstitution

See Certificate of Analysis for reconstitution instructions and specific concentrations.

Storage

Avoid repeated freeze-thaw cycles.

No activity loss was observed after storage at:
In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC).

 

SDS-PAGE


Rhesus macaque EpCAM / TROP1 Protein
The purity of Rhesus macaque EpCAM, His Tag was determined by DTT-reduced (+) SDS-PAGE and staining overnight with Coomassie Blue.
 
 

Background

EpCAM is also known as CO171A,; EGP; EGP40; GA7332; KSA; M4S; MIC18; MK1; TROP1; hEGP2, and is a pan-epithelial differentiation antigen that is expressed on almost all carcinomas as 17-1A(mAb) antigen. Its constitutional function is being elucidated. It is intricately linked with the Cadherin-Catenin pathway and hence the fundamental WNT pathway responsible for intracellular signaling and polarity. The epithelial cell adhesion molecule (Ep-CAM) is known to express in most epithelial malignancies and was reported as a tumor marker or a candidate of molecular targeting therapy. Ep-CAM cross signaling with N-cadherin involves Pi3K, resulting in the abrogation of the cadherin adhesion complexes in epithelial cells was reported. And Epithelial cell adhesion molecule (Ep-CAM) recently received increased attention as a prognostic factor in breast cancer.

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References