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Human MSR1 / CD204 Protein  pdf  pdf  pdf


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MS1-H5226-100ug
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Synonym

MSR1,CD204,SCARA1,SR-A,phSR1,phSR2

Source

Human MSR1, His Tag (MS1-H5226) is expressed from human 293 cells (HEK293). It contains AA Lys 77 - Leu 451 (Accession # NP_619729).

Predicted N-terminus: Lys 77

Molecular Characterization

MSR1( Lys 77 - Leu 451)NP_619729
Poly-his

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 42.1 kDa. The protein migrates as 65-72 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Endotoxin

Less than 1.0 EU per μg by the LAL method.

 

Purity

>95% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

Reconstitution

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Storage

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

No activity loss is observed after storage at:

  1. 4-8°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

SDS-PAGE

Human MSR1, His Tag (Catalog # MS1-H5226) SDS-PAGE gel

Human MSR1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

 

Background

Macrophage scavenger receptor 1 (MSR1) is also known as CD204, SCARA1, SR-A, and is class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. Defects in MSR1 may be a cause of prostate cancer (PC) or Barrett esophagus (BE).

References

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