Browse Products By Molecule:

Products --> Immune Checkpoint Proteins

Mouse PD-L1 / B7-H1 Protein, mouse IgG2a Fc Tag, low endotoxin  pdf  pdf  pdf


Cat-Pack Size Price(USD) Qty Inventory Order
Quote for bulk   Worldwide Shipping & Payment
PD1-M52A2-100ug
    $290.00
PD1-M52A2-1mg
    $2100.00
In-Stock
Place Purchase Orders


Synonym

PD-L1,CD274,B7-H1,PDCD1L1,PDCD1LG1

Source

Mouse PD-L1 / B7-H1 Protein, mouse IgG2a Fc Tag, low endotoxin, Phe 19 - Thr 238 (Accession # NP_068693) was produced in human 293 cells (HEK293) at ACROBiosystems.

Molecular Characterization

PD-L1 (Asp 16-Ser 289)NP_068693

Fc (Glu 98-Lys 330)P01863

This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 51.8 kDa. The protein migrates as 65-85 kDa on a SDS-PAGE gel under reducing (R) condition due to glycosylation.

Endotoxin

Less than 0.1 EU per μg by the LAL method.

Purity

>95% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

Reconstitution

See Certificate of Analysis for reconstitution instructions and specific concentrations.

Storage

Avoid repeated freeze-thaw cycles.

No activity loss was observed after storage at:
In lyophilized state for 1 year (4°C); After reconstitution under sterile conditions for 3 months (-70°C).

 

SDS-PAGE


Mouse PD-L1 / B7-H1 Protein, mouse IgG2a Fc Tag, low endotoxin
Mouse PD-L1, mouse IgG2a Fc Tag, low endotoxin on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
 
 

Background

Programmed cell death 1 ligand 1 (PDL1) is also known as B7-H, B7H1, MGC142294, MGC142296, PD-L1, PDCD1L1 and PDCD1LG1,which is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses.PDL1 is a cell surface immunoglobulin superfamily with two Ig-like domains within the extracellular region and a short cytoplasmic domain. This protein is broadly expressed in the majority of peripheral tissues as well as hematopoietic cells. Interaction between PDL1 and its receptors belonging to the CD28 family of molecules provide both stimulatory and inhibitory signals in regulating T cell activation and tolerance. PDL1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression.

Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.


References