Browse Products By Molecule:

Products --> Bio-Markers & CD Antigens

Human EpCAM / TROP1 Protein  pdf  pdf  pdf


Cat-Pack Size Price(USD) Qty Inventory Order
Quote for bulk   Worldwide Shipping & Payment
EPM-H5223-100ug
    $260.00
EPM-H5223-1mg
    $1440.00
In-Stock
Place Purchase Orders


Synonym

EPCAM,TACSTD1,TROP1,CD326,DIAR5,EGP2,EGP314,EGP40, ESA,GA733-2,HNPCC8,HNPCC-8,KS1/4,KSA,M4S1,MIC18,MK1

Source

Human EpCAM / TROP1 Protein, Gln 24 - Lys 265 (Accession # AAH14785.1) was produced in human 293 cells (HEK293) at ACROBiosystems.

Molecular Characterization

EpCAM (Gln 24-Lys 265)AAH14785.1

polyhistidine

Human EpCAM, His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 29 kDa. The predicted N-terminus is Gln 24. The reducing (R) protein migrates as 33-36 kDa in SDS-PAGE due to glycosylation.

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Purity

>95% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

Reconstitution

See Certificate of Analysis for reconstitution instructions and specific concentrations.

Storage

Avoid repeated freeze-thaw cycles.

No activity loss was observed after storage at:
In lyophilized state for 1 year (4°C); After reconstitution under sterile conditions for 3 months (-70°C).

 

SDS-PAGE


Human EpCAM / TROP1 Protein
Human EpCAM, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
 

Citations

Background

EpCAM is also known as CO171A, EGP, EGP40, GA7332, KSA, M4S, MIC18, MK1, TROP1, hEGP2, and is a pan-epithelial differentiation antigen that is expressed on almost all carcinomas as 17-1A(mAb) antigen. Its constitutional function is being elucidated. It is intricately linked with the Cadherin-Catenin pathway and hence the fundamental WNT pathway responsible for intracellular signaling and polarity. The epithelial cell adhesion molecule (Ep-CAM) is known to express in most epithelial malignancies and was reported as a tumor marker or a candidate of molecular targeting therapy. Ep-CAM cross signaling with N-cadherin involves Pi3K, resulting in the abrogation of the cadherin adhesion complexes in epithelial cells was reported. And Epithelial cell adhesion molecule (Ep-CAM) recently received increased attention as a prognostic factor in breast cancer.

Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.


References