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Rhesus macaque EGF R Protein, Fc Tag  pdf  pdf  pdf


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EGR-C5252-100ug
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Synonym

EGFR,ERBB,ERBB1,HER1,PIG61,mENA

Source

Recombinant Rhesus Macaque EGFR /ErbB1 Protein, C-Fc Tag (Rhesus Macaque EGFR / ErbB1 Fc Chimera) Leu 25 - Ser 645 (Accession # P55245) was produced in human 293 cells (HEK293) at ACROBiosystems.

Molecular Characterization

Rhesus Macaque EGFR / ErbB1 Fc Chimera is fused with a human IgG1 Fc tag at the C-terminus, and has a calculated MW of 95.3 kDa. The predicted N-terminus is Leu 25. DTT-reduced Protein migrates as 130-140 kDa in SDS-PAGE due to glycosylation.

Endotoxin

Less than 1.0 EU per μg of the Rhesus Macaque EGFR / ErbB1 Fc Chimera by the LAL method.

Purity

>95% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in 50 mM tris, 100 mM glycine, pH7.5. Normally Mannitol or Trehalose are added as protectants before lyophilization.

Contact us for customized product form or formulation.

Reconstitution

See Certificate of Analysis for reconstitution instructions and specific concentrations.

Storage

Avoid repeated freeze-thaw cycles.

No activity loss was observed after storage at:
In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC).

 

SDS-PAGE


Recombinant Rhesus Macaque EGFR /ErbB1 Protein, C-Fc Tag
The purity of Rhesus Macaque EGFR / ErbB1 Fc Chimera was determined by DTT-reduced (+) SDS-PAGE and staining overnight with Coomassie Blue.
 
 

Background

The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Mutations affecting EGFR expression or activity could result in cancer.

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References