Recombinant Rhesus Macaque EGFR /ErbB1 Protein, C-Fc Tag (Rhesus Macaque EGFR / ErbB1 Fc Chimera) Leu 25 - Ser 645 (Accession # P55245) was produced in human 293 cells (HEK293) at ACROBiosystems.
Rhesus Macaque EGFR / ErbB1 Fc Chimera is fused with a human IgG1 Fc tag at the C-terminus, and has a calculated MW of 95.3 kDa. The predicted N-terminus is Leu 25. DTT-reduced Protein migrates as 130-140 kDa in SDS-PAGE due to glycosylation.
Less than 1.0 EU per μg of the Rhesus Macaque EGFR / ErbB1 Fc Chimera by the LAL method.
>95% as determined by SDS-PAGE.
Lyophilized from 0.22 μm filtered solution in 50 mM tris, 100 mM glycine, pH7.5. Normally Mannitol or Trehalose are added as protectants before lyophilization.
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See Certificate of Analysis for reconstitution instructions and specific concentrations.
Avoid repeated freeze-thaw cycles.
No activity loss was observed after storage at:
In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC).
The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Mutations affecting EGFR expression or activity could result in cancer.
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