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Mouse gp130 / CD130 / IL-6 R beta Protein  pdf  pdf  pdf


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Synonym

IL6ST,gp130,CD130,IL-6RB,IL-6R-beta,CDw130

Source

Mouse gp130 / CD130 / IL-6 R beta Protein, Gln 23 - Glu 617 (Accession # NP_034690) was produced in human 293 cells (HEK293) at ACROBiosystems.

Molecular Characterization

IL-6 R beta (Gln 23-Glu 617)NP_034690

polyhistidine

Mouse gp130, His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 68.5 kDa. The predicted N-terminus is Gln 23. The reducing (R) protein migrates as 85-100 kDa in SDS-PAGE due to glycosylation.

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Purity

>95% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Trehalose is added as protectant before lyophilization.

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Reconstitution

See Certificate of Analysis for reconstitution instructions and specific concentrations.

Storage

Avoid repeated freeze-thaw cycles.

No activity loss was observed after storage at:
In lyophilized state for 1 year (4°C); After reconstitution under sterile conditions for 3 months (-70°C).

 

SDS-PAGE


Mouse gp130 / CD130 / IL-6 R beta Protein
Mouse gp130, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
 
 

Background

Interleukin-6 receptor subunit beta (IL6ST) is also known as IL-6 receptor subunit beta, IL-6R subunit beta, IL-6R-beta, IL-6RB, Interleukin-6 signal transducer, Membrane glycoprotein 130 (gp130), CD130, Oncostatin-M receptor subunit alpha and Il6st,which is single-pass type I membrane protein. IL6ST /gp130 /CD130 can be found in tissues such as brain, heart, thymus, spleen, kidney, lung and liver and found in all the cell lines tested except BaF-B03.The expression of IL-6ST /gp130 is not restricted to IL6-responsive cells. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. IL6ST /CD130 can bind to IL6 /IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduce the signal. IL6ST /GP130 does not bind IL6 and may have a role in embryonic development.

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References

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