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Your Position: Home > Nectin-2

Nectin-2

Brief Information

Name:Transmembrane protein PVRIG
Target Synonym:PVRIG,PVR Related Immunoglobulin Domain Containing,CD112 Receptor,Poliovirus Receptor-Related Immunoglobulin Domain-Containing Protein,Poliovirus Receptor Related Immunoglobulin Domain Containing,Nectin-2 Receptor,C7orf15,CD112R,Transmembrane Protein PVRIG,MGC2463
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:7
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
CD2-H82E7 Human Biotinylated Human Nectin-2 / CD112 Protein, His,Avitag™ (MALS verified)
CD2-H82E7-structure
CD2-H82E7-sds
CD2-H82A3 Human Biotinylated Human Nectin-2 / CD112 Protein, Mouse IgG2a Fc,Avitag™ (MALS verified)
CD2-H82A3-structure
CD2-H82A3-sds
CD2-H5257 Human Human Nectin-2 / CD112 Protein, Mouse IgG2a Fc Tag
CD2-H5257-structure
CD2-H5257-sds
CD2-H82F8 Human Biotinylated Human Nectin-2 / CD112 Protein, Fc,Avitag™ (HPLC verified)
CD2-H82F8-structure
CD2-H82F8-sds
CD2-H82F8-hplc
PV2-H5253 Human Human Nectin-2 / CD112 Protein, Fc Tag
PV2-H5253-structure
PV2-H5253-sds
PV2-H52E2 Human Human Nectin-2 / CD112 Protein, His Tag
PV2-H52E2-structure
PV2-H52E2-sds
ACRO Quality

Part of Bioactivity data

CD2-H5257-BLI
Nectin-2 BLI

Loaded Human Nectin-2, Mouse IgG2a Fc Tag (Cat. No. CD2-H5257) on Protein A Biosensor, can bind Human PVRIG, His Tag (Cat. No. PVG-H52H4) with an affinity constant of 1.33 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol
PV2-H5253-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human Nectin-2, Fc Tag (Cat. No. PV2-H5253) on Protein A Biosensor, can bind Human PVRIG, His Tag (Cat. No. PVG-H52H4) with an affinity constant of 0.456 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol

Synonym Name

CD112,Nectin-2,PVRL2

Background

Poliovirus receptor-related 2 (PVRL2) is also known as nectin-2 and CD112 (formerly herpesvirus entry mediator B, HVEB),  which is a human plasma membrane glycoprotein. PVRL2 is one of the plasma membrane components of adherens junctions. PVRL2 also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in PVRL2 gene have been associated with differences in the severity of multiple sclerosis. Also, PVRL2 binds with low affinity to TIGIT. Furthermore, PVRL2 acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV).

Clinical and Translational Updates

Related Molecule

TIGIT DNAM-1

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
SIM-0348 SIM-0348 Phase 1 Clinical Simcere Pharmaceutical Group Ltd Solid tumours; Neoplasms Details
PM-1009 PM1009 Phase 1 Clinical Biotheus Inc Solid tumours; Neoplasms; Lung Neoplasms Details
COM-701 COM-701 Phase 2 Clinical Compugen Ltd Ovarian Neoplasms; Head and Neck Neoplasms; Solid tumours; Triple Negative Breast Neoplasms; Neoplasms; Breast Neoplasms; Colorectal Neoplasms; Endometrial Neoplasms; Lung Neoplasms Details
NM1F NM1F; TGI-2 Phase 1 Clinical Hefei TG ImmunoPharma Co Ltd Ovarian Neoplasms; Solid tumours; Triple Negative Breast Neoplasms; Colorectal Neoplasms; Melanoma Details
SHR-2002 SHR-2002 Phase 1 Clinical Suzhou Suncadia Biopharmaceuticals Co Ltd, Shanghai Hengrui Pharmaceutical Co Ltd Neoplasms Details
JS-009 JS-009; TAB009 Phase 1 Clinical Shanghai Junshi Biosciences Co Ltd Solid tumours; Neoplasms Details
GSK-4381562 SRF-813; GSK-4381562 Phase 1 Clinical Surface Oncology Inc Neoplasms Details

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